Endocrine Abstracts

Endorsed by the European Journal of Endocrinology )-->Central neck dissection for papillary thyroid cancer (PTC) was initially proposed by Scandinavian authors in the late 70’s on the following grounds: i) the common presence of obvious metastatic nodal disease in compartment VI; ii) compartment VI is the first step in lymph node dissemination of PTC; and iii) prevents cancer recurrence in the ce...

A C Bianco is a professor of medicine and Chief of the Division of Endocrinology, Diabetes and Metabolism at the University of Miami Miller School of Medicine. Dr A C Bianco obtained his MD, PhD and clinical training in internal medicine and endocrinology in Sao Paulo, Brazil. His work has established the importance of the local control of thyroid hormone activation/inactivation via deiodination, as well as fundamental cellular and molecular properties of the deiodinases (D1, ...

Case historyA 27 year-old woman presents with a right 3 cm. papillary thyroid cancer (PTC) with lateral cervical lymph node metastasis. Her past history is irrelevant. Treatment consists of total thyroidectomy plus lymphadenectomy of compartments II-III-IV-VI. iPTH and s-Ca concentrations at 24 h were 6 pg/ml and 7 mg/dl respectively. Replacement therapy (calcium + calcitriol) was required for three months (protracted hypoparathyroidism). Pathology r...

The patient is a 45 year old gentleman known case of HIV seropositivity (well-controlled, undetectable viral load) and polycystic kidney disease, who was referred to our Endocrine clinic by the Infectious disease specialists in view of a 4 year history of erectile dysfunction (ED – preceded diagnosis of HIV) and a low testosterone level. During the first consultation, the patient reported occasional lethargy and long term nausea which was attributed to his retroviral trea...

Gender Dysphoria (GD) is defined as incongruence between gender identity and physical phenotype. This condition exists in different psychological typologies: male-to-female (MtF) and female-to-male (FtM) transsexualism. In most cases the first manifestations can occur even during childhood. The transition project is a long and difficult path that involves a multidisciplinary team including endocrinologists, psychologist and plastic surgeons. Our study aims to describe socio-de...

In MtFs therapy with oestrogens and antiandrogens, actually considered the best strategy, requires a careful baseline and follow-up hormonal evaluation. We conducted a retrospective analysis to define the most frequent hormonal treatment prescribed and the relationship between the dosage and patients’ hormonal changes. Among 85 pts referring to us between March 2003 and June 2018 with a mean age of 28.4 years we have selected 42 treated with Oestradiol Valerate (OV) and C...

In FtMs testosterone (TE) therapy is used to pursue the dual objective of suppressing female secondary sex characteristics and inducing a male phenotype to the patient. Between October 2001 and December 2018, an heterogeneous group of 32 patients (Pts) with a mean age of 27.7 years presented to our Center for FtM Gender Dysphoria. We analyzed Body Mass Index (BMI), haemochrome and hormonal (LH, FSH, Prolactin) measurements comparing baseline levels to post-therapy. A total of ...

Background: Low testosterone (T) is frequent in men with chronical illnesses. The clinical features of T deficiency (TD) overlap with those of chronic diseases. The aim of this study is to evaluate the relative contribution of chronic disease score (CDS) and low T to the presence of TD symptoms.Methods: A consecutive series of 3862 men (aged 52.1±13.1 years) consulting for sexual dysfunction was studied. Several clinical and biochemical parameters w...

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 7–18% of women of reproductive age, according to different criteria. Metabolic disturbances related to PCOS include dyslipidemia, obesity, and insulin resistance (IR) and women with PCOS have higher prevalence of impaired glucose tolerance and type 2 diabetes mellitus in comparison with weight-matched women without the syndrome. Evidence indicates that regular practice of physical activity improves ...

Introduction: Pregnancy in a patient with acromegaly is uncommon, as the enlarging pituitary adenoma suppresses gonadotropin secretion rendering the patient amenorrhoeic and infertile. About 40% of the women with pituitary adenomas also have hyperprolactinaemia, which further decreases the likelihood of pregnancy.Case report: A 32-year-old woman was sent to our centre in the first trimester of pregnancy with the diagnostic of gestational diabetes. Clinic...